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Research

THE RESEARCH SHOWS:

1.  There is a Brain Gut Health Connection

2.  Infectious Diseases Can Act As Health Triggers

Knowing this research, please learn how some omega and plant ingredients help elevate an individual’s immune, brain and gut health.

BOSWELLIN

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Boswellin is a standardized powdered extract from the Gum resin exudates of Boswellia serrata tree, commonly known as FRANKINCENSE.  It contains 4 identified triterpenoid B-Boswellic acids. The four major identified pentacyclic triterpenoids in Boswellin are B-Boswellic acid, Acetyl-B-Boswellic acid, 11-keto-B-Boswellic acid and Acetyl-11-keto-B-Boswellic acid (AKBBA).


Traditional Knowledge


Frankincense, also known as olibanum, has a long history of use for example, in religious ceremonies and for its medicinal properties that have been appreciated for millennia in China and India.  Furthermore, frankincense has traditionally been used medicinally as a remedy for a wide variety of afflictions and ailments, including infections, ulcers, nausea and fever. In India, the gum resin exudates of Boswellia serrata has been used in the Ayurvedic system of medicine in the management of several inflammatory conditions.  A study documented with the NIH foundbioactivity of frankincense essential oil significantly overlapped with many canonical pathways signaling pathways that are closely related to thebiological processes of inflammation, immune response, and tissue remodeling in human cells.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801908/  


Mechanism of Action


Boswellic acids have been shown to inhibit 5-lipoxygenase, an enzyme that catalyzes the formation of pro-inflammatory leukotrienes from arachidonic acid.  In addition to this mechanism, boswellic acids also decrease the activity of the enzyme, Human Leukocyte Elastase (HLE). This dual action is unique to boswellic acids.  

Ammon HP et al. (1993) J. Ethanopharmacol. Mar. 38(2-3: 113-9

Safayhi H et al.  (1997) J. Pharmaco. Exp Ther. 281: 460-463


Nutraceutical Application

Boswellin with its high AKBBA content, finds potential use in management of various inflammatory disorders and healthy joint support.


Management of Arthritis

Boswellin has anti-inflammatory action much like conventional non steroidal anti-inflammatory drugs (NSAIDs).  Additionally, long term usage of Boswellia does not lead to irritation or ulceration of the stomach, therefore safer than NSAIDS.


Management of Respiratory Disorders

Leukotrienes have a major role in the effects related to asthma, allergies and inflammation.  Hence inhibition of 5-Lipoxygenase enzyme is most important in management of asthma. In a double blind placebo controlled study, 70% of the patients treated with Boswellia serrata improved in comparison to control including disappearance of physical symptoms decrease eosinophilic count and improvement of respiratory rate.

Gupta, l. et al.  (1998) Eur. J. Med Res.  3(11):511-514)


Management of Ulcerative colitis

Patients suffering from ulcerative colitis were treated with Boswellia serrata extract (350 mg x 3 times; n=34) and Sulfasalazine (1g x 3 times; n=8) for 6 weeks.  The author observed that 82% of the patients treated with Boswellia extract showed improvement. 

Gupta, I. et al. (1997) Eur. J. Med. Res. 2: 37-43)


Boswellia vs Valdecoxib on Osteoarthritis

In a comparative study of Valdecoxib 10 mg daily vs Boswellia serrata extract (BSE 40%) 333 mg, 3 times daily involving 66 subjects.  It is found that Boswellia serrata extract was superior to Valdecoxib in terms of Safety, Efficacy and Duration of action.

Sontakke et al (2007) Indian J. Pharmacol. 39(1): 27-29

CURCUMIN

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Curcumin is obtained from the dried rhizomes of Curcuma longa (Turmeric) and standardized for minimum 95% Curcuminoids.  


There are three main chemical compounds - Curcumin, Demethoxycurcumin (DMC) and Bisdemethoxycurcumin (BDMC) - collectively known as Curcuminoids.


The rhizome of turmeric (Cucuma longa L.) has a rich history in India as a spice, food preservative and has been used for centuries in the Ayurvedic system of medicine.  In Ayurvedic medicine, turmeric is well-documented for treatment of various respiratory conditions (ie, asthma, bronchial hyperactivity, and various allergies), liver disorders, poor appetite, rheumatism, and influenza symptoms.  


At a molecular level, the curcuminoids have been shown to inhibit nuclear factor kappaB (NFkB) a transcription factor that triggers inflammatory mediators.  NFkB is implicated in a variety of chronic disease conditions ranging from cardiovascular diseases to cancer. Curcuminoids offer antioxidant support, anti inflammatory support, supports a healthy immune system and potentially prevent connective tissue break down through inhibiting destructive enzymes, with benefits to healthy aging (Aggarwal B. et al. (2006). Turmeric: The Genus Curcuma.  Pp 297-368).


Hello Heath’s curcumin uses the only curcumin in the market that:

  1.  Has been reviewed and acknowledged by US FDA for GRAS status, a process which includes a comprehensive review of safety and toxicology data.
  2. Holds patents covering composition of curcuminoids, method of manufacture and uses.
  3. Consistently has the same composition of the three curcuminoids in the same ratio in every batch.
  4. Proven bioavailability
  5. NBJ Scientific Achievement Award

Anti-inflammatory: Fighting Inflammation

Most degenerative diseases are driven by chronic subclinical inflammation.  The old view of the inflammation is that it represents the healing process. This is true to a certain extent; however when the inflammation becomes chronic, it becomes a disease.  


Today, the study of inflammation has gone from the tissue levels deeper into the nuclear level.  Cell-signaling molecules have been identified which stimulate the gene that induces the expression of the COX enzyme which in turn induce inflammation.


“NF-kB: The master regulator of Inflammation”

Nuclear Factor - Kappa B (NF-kappa B), as the ‘master switch’, is the primary means by which inflammation is ‘adjusted’.

In the normal state, 

  • NF-kB resides in the cytoplasm of the cell and is bound to its inhibitor -IkB (Inhibitor of k-B.)
  • Injuries and inflammatory stimuli, such as free radicals, release NF-kB from its inhibitor-IkB
  • The free NF-kB, now moves into the nucleus and activates the genes responsible for expressing cyclooxygenase-2 (COX-2).
  • This leads to inflammation

NF-kB activation is a major mediator of inflammation in most diseases and inhibition of NF-kB can help prevent/delay the onset of the disease.  Curcuminoids' natural compounds derived from turmeric roots, inhibit NF-kB.


Inflammation plays a major role in development of most diseases.


Anticancer:

Curcuminoids act by inhibiting several processes that contribute to the survival, proliferation, invasion and metastasis of tumor cells (Kuttan G. et al. (2007) Adv Exp Med Biol, 595: 173-84).


Curcuminoids act by interfering with signaling mechanisms (critical for tumor growth), regulation of apoptosis (cell death), and tumor angiogenesis (new blood vessel formation which feeds tumors).


Phase I clinical trials have shown that curcuminoids are safe at doses up to 8 g/day (Cheng AL. et al. (2001). Anticancer Res. 2895-900).


Alzheimer’s Study:

A group of researchers from UCLA treated macrophages of six Alzheimer disease (AD) patients with curcuminoids in vitro and measured anti-amyloid B (AB) uptake using fluorescence and confocal microscopy.  After treatment AB uptake by macrophages of three of the six AD patients was significantly increased. Confocal microscopy of AD macrophages responsive to curcuminoids showed surface binding in untreated macrophages but co-localization with phalloidin in an intracellular compartment after treatment (Zhang L. et al. (2006). J. Alzheimers Dis. 10(1): 1-7).

PHOSPHATIDYLSERINE

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Sharp PhosphatidylSerine (PS) is a naturally occurring phospholipid that is consumed as part of a normal diet.  Clinical studies indicate that supplemental Phosphatidylserine may be beneficial for memory loss conditions, cognitive performance, improving mood and learning disabilities.


Hello Health’s soy-free PhosphatidylSerine is a novel, all-natural source of Phosphatidylserine produced from sunflower lecithin from sunflowers that are grown on controlled farms in Europe and have a lower impact on the environment.  Unlike traditional soy-based phosphatidylserine, it is soy-free and allergen-free, making it an excellent option for those seeking allergen-free and non-GMO.


People can boost their intake of phosphatidylserine though food—it's available in a number of foods, including soy (which is the main source), white beans, egg yolks, chicken liver, and beef liver.  However, the modern diet has changed making it hard to get PS naturally due to more processed foods, lower good fats, fewer meats and a faster more urban life.


In over 30 clinical studies studied over whole populations in memory and cognitive decline found that cognitive abilities (e.g. memory, learning, and attention) and brain functioning related parameters increased with 100 mg/day. (Published in Chinese in: Tang Yong et al, Chongqing medical journal).  Additionally, PS is the only cognitive supplement with FDA health claims.


Hello Health uses Sharp PS which has been clinically proven to:

  • Improve memory, mood and learning
  • Slow the effects of aging on memory
  • Improve exercise experience
  • Improved recovery
  • Reduced muscle soreness

 

As with any supplement, please consult your health care practitioner before using. Keep out of reach of children.  These statements have not been evaluated by the Food and Drug Administration. Hello Health products are not intended to diagnose, treat, cure, or prevent any disease. 

CINNAMON OIL

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Cinnamon can aid in eliminating bacterial and viral infections. From some studies, it was noted that cinnamon oil has antimicrobial properties. Cinnamon is also used to soothe respiratory illnesses such as colds, sinusitis, and sore throats, as well as it helps to relieve muscular aches and pains. It has also been used for weight loss, and it keeps blood sugar levels balanced, prevents sugar cravings, mood swings and fatigue. In addition to fighting bacterial and viral infections, it is also known to fight parasites plus relieve depression and anxiety.  Also, cinnamon works when it comes to gut health. Cinnamon contains calcium and fiber that are the essential components for the functioning of the colon. The colon pulls out waste. This supports detoxification, good digestive health and it also helps in preventing issues like constipation and diarrhea. 

PARSLEY

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A widely used vegetal species in various nations' medicine is parsley (Petroselinum crispum).  Parsley is a native herb of the central Mediterranean region (southern Italy, Algeria and Tunisia), which is in the Apiaceae family, and is a species of Petroselinum.

It is believed that parsley is one of the world's seven most potent disease-fighting spices used to treat allergy, autoimmune and chronic inflammatory disorders.  Parsley is a herb that is rich in many nutrients such as vitamins A, C, K, potassium, magnesium and calcium. Vitamin A in parsley helps in improving eye health, skin conditions, and immunity.  Vitamin C in it is known to enhance the immune system and heart health.

Research shows that apigenin — an antioxidant in parsley — regulates immune function by reducing inflammation and preventing cellular damage.

Parsley extract contains myristicin and apiol, which have antibacterial effects.  Further, parsley juice supports the detoxification processes of the liver and kidneys.

ZINC

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From research published in PLOS Pathogens, it was noted that mice whose immune system was zinc deficient succumbed to infection up to 3 times faster. That means zinc can help in killing the bacteria. Also, in a study by Daren Knoell (a professor at Ohio State University), he states that zinc helps in balancing the response of the immune system by fighting infections.  

OLIVE LEAF EXTRACT

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It is a kind of miracle extract that comes from the leaves of the olive tree. It is known to offer a range of health benefits like treating diarrhea, Alzheimer’s, osteoporosis, shingles, urinary tract infections, etc. According to research, olive leaf extract contains oleuropein that has antibacterial, immune-stimulating, anti-cancer, and anti-inflammatory properties. It lowers cholesterol, reduces high blood pressure and has many other properties. 

Resources and Research:

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  1. https://sarkis.caltech.edu
  2. http://www.scientificamerican.com/article/molecular-tweeting-could-hold-the-key-to-busting-superbugs/
  3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604320/
  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589978/
  5. http://www.ncbi.nlm.nih.gov/pubmed/11973156
  6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193870/
  7. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924999/
  8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601973/
  9. http://www.pandashopeforhealing.com/Research-Articles
  10. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099351/
  11. http://www.hindawi.com/journals/grp/2012/457150/
  12. http://www.ncbi.nlm.nih.gov/pubmed/20030464
  13. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921083/
  14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583392/
  15. http://www.ncbi.nlm.nih.gov/pubmed/24756059
  16. http://www.ncbi.nlm.nih.gov/pubmed/22784340
  17. http://www.ncbi.nlm.nih.gov/pubmed/22784340
  18. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500832/
  19. http://www.ncbi.nlm.nih.gov/pubmed/9430014
  20. http://www.ncbi.nlm.nih.gov/pubmed/24283351
  21. http://www.ncbi.nlm.nih.gov/pubmed/25500493
  22. http://www.ncbi.nlm.nih.gov/pubmed/26293583
  23. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990147/
  24. http://www.raindroptraining.com/research/index.shtml
  25. https://www.hms.harvard.edu/dms/immunology/fac/Walker.php
  26. http://www2.massgeneral.org/mucosalimmunology/research/lab-cherayil.html
  27. http://www2.massgeneral.org/mucosalimmunology/pub/pub-cherayil.html
  28. http://www2.massgeneral.org/mucosalimmunology/pub/pub-faherty.html
  29. http://www2.massgeneral.org/mucosalimmunology/pub/pub-fasano.html
  30. http://www2.massgeneral.org/mucosalimmunology/pub/pub-gobel.html
  31. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662178/
  32. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463494/
  33. http://fiveelementhealing.net/in-depth-healing-strategies-for-lyme-disease-new/
  34. https://www.youtube.com/watch?v=1WtS8cm4mOg
  35. http://www.rnoel.50megs.com/pdf/theblood.htm
  36. The need for natural ingredients to remove bacterial and viral elements from the body to prevent damage includes:
  37. https://www.beyondceliac.org/research-news/View-Research-News/1394/postid--107060/
  38. https://eurekalert.org/pub_releases/2019-02/b-cvi021119.php
  39. https://www.beingpatient.com/herpes-virus-is-linked-to-half-of-alzheimers-says-expert/
  40. https://www.alzforum.org/news/research-news/aberrant-networks-alzheimers-tied-herpes-viruses
  41. The need for gut health to help depression and anxiety:
  42. https://www.everydayhealth.com/columns/therese-borchard-sanity-break/ways-cultivate-good-gut-bacteria-reduce-depression/
  43. https://www.psycom.net/the-gut-brain-connection
  44. https://www.viome.com/blog/anxiety-depression-your-gut-microbiome-blame

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